Jiří Damborský and Zbyněk Prokop have won a Masaryk University (MUNI) Innovation Award for their pioneering commercialisation efforts .
Enantis is the first biotechnology spin-off of Masaryk University. Inspired by the colleagues at Groningen University in The Netherlands, Enantis was started by Zbynek Prokop and Jiri Damborsky when Masaryk University did not have a tech-transfer office. With the great help of the young South Moravian Innovation centre, establishing a technology company helped cultivate an academic environment and set up necessary processes for effective transfer of results from academic research to practice. Other companies followed. Enantis is currently known for the production of hyperstable growth factors essential for the cultivation of stem cells (FGF2), which were engineered using the platform developed by the Loschmidt Laboratories. Both Loschmidt Laboratories and Enantis are Es-Cat partners and benefited from the creative and collaborative ecosystem of this European network.
Goal The course aims to make participants familiar with the use of structural biology and computational tools for engineering the performance of enzymes that are relevant for applied biocatalysis and synthetic biology. The course provides both a theoretical background on computational methods relevant to enzyme engineering (protein crystallography, homology modeling, energy calculations, protein design, smart libraries), and hands-on computer exercises on visualization and analysis of enzymes structures, including docking simulations and enzyme redesign. The theoretical and practical parts are integrated in a few problem-solving modules. Participants will have the opportunity to share their research via short oral presentations, posters, and interactive lectures.
Topics Protein crystallography and structure analysis Homology modeling, docking and molecular dynamics simulations (Yasara) Computational enzyme (re)design (Rosetta) Enzyme engineering supported by web tools Sequence- and structure-based smart libraries Thermostability and stereoselectivity engineering Industrial examples of enzyme engineering
Tutors and teachers Dick Janssen, University of Groningen Hein Wijma, University of Groningen Andy-Mark Thunnissen, University of Groningen Jiri Damborsky, Masaryk University, Brno David Bednar, Masaryk University, Brno Marc van der Kamp, University of Bristol Rene de Jong, DSM Delft Emanuele Monza, Zymvol, Barcelona
Masterclass coordination Dick Janssen, Hein Wijma, University of Groningen, The Netherlands Jiri Damborsky and David Bednar, Masaryk University, Brno, Czech Republic Sandra Haan & Tamara Hummel, GBB, University of Groningen, The Netherlands
Intended participants PhD students, post docs and other researchers skilled in biochemistry who want to become familiar with structure-based and computational approaches in Enzyme Engineering. Partners of the H2020 ES-Cat and other EU collaborative projects and training networks are offered priority reduced fee registration. Note: participants are offered the opportunity to share their research via posters and participant talks.
To Apply Details will follow. For info: firstname.lastname@example.org.